Teri VO:
Hi, I'm Teri. I'm from the Gulf Coast of Florida. I would like to share my MDS-related anemia story.

Sheri VO:
Hi, my name is Sheri and I'm not only Teri's twin sister, I'm also her healthcare advocate and caregiver.

Teri VO:
In 2009, I received a hip replacement and at that time I needed a blood transfusion. I then was checked every couple months and my hemoglobin started dropping gradually over time.

My emotional state during that period was, you know, 'There's something wrong with me.' I just never used to vocally say, 'I'm so tired.'

And as that time goes on, when my hemoglobin lowered, it became more prevalent.

We'd be on the beach and we would be taking a walk ...and I'd say, 'I got, I got to stop. I'm just like really, really tired.' It's just a feeling of being drained. That's how I would describe it. Color goes out of your face ...you become pale. And then just wanting to lay down.

I was diagnosed with MDS actually in, I believe it was 2011. I had never known anyone that had a bone marrow cancer.

So when I was diagnosed I was only worried about dying.

Sheri VO:
I was scared because of that word cancer, the big C, and on it being a bone marrow disease ..

Sheri VO:
it just sounded, you know, very scary and wondering about how long I would have her.

Teri VO:
... I'm sorry

Sheri VO:
It's okay ...

Teri VO:
The injections, you know, I expected them, so they were done every week.

My journey to the treatment center was 38 miles each way ...That's a long trip.

The hardest part of it is that…you take all this time to go over there and it becomes a whole day of your, of your week. I didn't realize how much time I was really missing.

Sheri VO:
Teri was not able to go on any kind ...of extended vacations when she was traveling to see her grandchildren ...It always had to be shorter trips.

We probably woulda gone a lot more places ...had she not been limited to having to have that done every week.

You know, our last trip to Mexico, I noticed that she had to lay down a lot more ...

When that happened, it was almost like, well, you know, you have to go to the next step.

ANNOUNCER VO:
We will hear the rest of the story in one minute, after this Important Safety Information.

REBLOZYL, also known as luspatercept, is a prescription medicine for injection, and is used to treat anemia (low red blood cells) in adults with:

• MDS who may need regular red blood cell transfusions, or RBC transfusions, and have never received another type of medicine called an erythropoiesis stimulating agent (ESA)
• MDS-RS or MDS/MPN-RS-T who need 2 or more RBC units, or red blood cell units, over 8 weeks and have not responded well to an ESA
  • REBLOZYL is not a substitute for RBC transfusions in people who need immediate treatment for anemia.
  • It is not known if REBLOZYL is safe or effective in children under 18 years of age.

What are the serious side effects of REBLOZYL?
REBLOZYL may cause serious side effects, including blood clots, also known as thrombosis or thromboembolism, and high blood pressure, also known as hypertension.

Please see Important Safety Information for REBLOZYL at www.REBLOZYL.com

Teri VO:
When my treatment started waning ...and it was obvious I was going to need to go on another one or be blood transfusion dependent, I was told about REBLOZYL.

I have to happily say that since I've been on REBLOZYL, I've not required any blood transfusions.

ANNOUNCER VO:
With REBLOZYL, nearly three times as many people had no red blood cell transfusions for at least 8 weeks compared to placebo.

Teri VO:
I started that and I noticed ...gradually that the first time I walked on the beach I could go a little farther.

Sheri VO:
Yeah. She's able to do a little bit more ...and feel more like 'Teri' ...in doing daily activities ... and also in ...attempting to do more physical activities.

Teri VO:
One of the nicest things about REBLOZYL. ..is that I would be able to go three weeks in between an injection ...Those three weeks have been like... a great advantage that I didn't know I was missing by going every week. It gives you a lot more time.

For the first time, I visited my daughter's family and I stayed there seven days.

So now I can plan a vacation with my husband or with Sheri, and I don't have to worry about getting back.

Today we are here to do our baskets. It started, though, wanting to do these little tiny kindness gifts for people that are sick.

Sheri VO:
And it's something we can do together.

Teri VO:
We always tell people they're made with love.

I would like to give my advice to those patients that have just been ...diagnosed with MDS-related anemia.

Find a doctor that understands MDS ...has worked with MDS patients, or can refer you to ...someone that is a professional in that.

I want to also give you hope. Because at the end of the day, it's all about time. Time is precious.

And now, maybe it's your time for REBLOZYL.

ANNOUNCER VO:
Ask your doctor if REBLOZYL is right for you.

Please see full Prescribing Information and Medication Guide for REBLOZYL at www.REBLOZYL.com